The Enzyme Database

Your query returned 2 entries.    printer_iconPrintable version

Accepted name: dihydropyrimidinase
Reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate
For diagram of pyrimidine catabolism, click here
Other name(s): hydantoinase; hydropyrimidine hydrase; hydantoin peptidase; pyrimidine hydrase; D-hydantoinase
Systematic name: 5,6-dihydropyrimidine amidohydrolase
Comments: Also acts on dihydrothymine and hydantoin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9030-74-4
1.  Brooks, K.P., Jones, E.A., Kim, B.-D. and Sander, E.G. Bovine liver dihydropyrimidine amidohydrolase: purification, properties, and characterization as a zinc metalloenzyme. Arch. Biochem. Biophys. 226 (1983) 469–483. [DOI] [PMID: 6639068]
2.  Eadie, G.S., Bernheim, F. and Bernheim, J.L.C. Metabolism of cytosine, thymidine, uracil and barbituric acid by bacterial enzymes. J. Biol. Chem. 181 (1949) 449–458. [PMID: 15393763]
[EC created 1961]
Accepted name: isatin hydrolase
Reaction: isatin + H2O = isatinate
Glossary: isatin = 1H-indole-2,3-dione
isatinate = 2-(2-aminophenyl)-2-oxoacetate
Systematic name: isatin amidohydrolase
Comments: Requires Mn2+. This enzyme, found in several bacterial species, is involved in the degradation of indole-3-acetic acid.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Sommer, M.R. and Jochimsen, B. Identification of enzymes involved in indole-3-acetic acid degradation. Plant Soil 186 (1996) 143–149.
2.  Bjerregaard-Andersen, K., Sommer, T., Jensen, J.K., Jochimsen, B., Etzerodt, M. and Morth, J.P. A proton wire and water channel revealed in the crystal structure of isatin hydrolase. J. Biol. Chem. 289 (2014) 21351–21359. [DOI] [PMID: 24917679]
[EC created 2014]

Data © 2001–2019 IUBMB
Web site © 2005–2019 Andrew McDonald