The Enzyme Database

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Accepted name: enamidase
Reaction: 6-oxo-1,4,5,6-tetrahydronicotinate + 2 H2O = 2-formylglutarate + NH3
For diagram of nicotinate catabolism, click here
Systematic name: 6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase
Comments: Contains iron and Zn2+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC (nicotinate dehydrogenase), EC (6-hydroxynicotinate reductase), EC (2-hydroxymethylglutarate dehydrogenase), EC (2-methyleneglutarate mutase), EC (methylitaconate Δ-isomerase), EC (dimethylmaleate hydratase) and EC (2,3-dimethylmalate lyase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Alhapel, A., Darley, D.J., Wagener, N., Eckel, E., Elsner, N. and Pierik, A.J. Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri. Proc. Natl. Acad. Sci. USA 103 (2006) 12341–12346. [PMID: 16894175]
[EC created 2006]

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