| EC |
3.5.1.94 |
| Accepted name: |
γ-glutamyl-γ-aminobutyrate hydrolase |
| Reaction: |
4-(γ-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate |
| Glossary: |
4-aminobutanoate = γ-aminobutyrate = GABA |
| Other name(s): |
γ-glutamyl-GABA hydrolase; PuuD; YcjL; 4-(γ-glutamylamino)butanoate amidohydrolase; 4-(L-γ-glutamylamino)butanoate amidohydrolase |
| Systematic name: |
4-(γ-L-glutamylamino)butanoate amidohydrolase |
| Comments: |
Forms part of a putrescine-utilizing pathway in Escherichia coli, in which it has been hypothesized that putrescine is first glutamylated to form γ-glutamylputrescine, which is oxidized to 4-(γ-glutamylamino)butanal and then to 4-(γ-glutamylamino)butanoate. The enzyme can also catalyse the reactions of EC 3.5.1.35 (D-glutaminase) and EC 3.5.1.65 (theanine hydrolase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Kurihara, S., Oda, S., Kato, K., Kim, H.G., Koyanagi, T., Kumagai, H. and Suzuki, H. A novel putrescine utilization pathway involves γ-glutamylated intermediates of Escherichia coli K-12. J. Biol. Chem. 280 (2005) 4602–4608. [DOI] [PMID: 15590624] |
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| [EC 3.5.1.94 created 2006, modified 2011] |
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