The Enzyme Database

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EC 3.5.1.113     
Accepted name: 2′′′-acetyl-6′′′-hydroxyneomycin C deacetylase
Reaction: 2′′′-acetyl-6′′′-deamino-6′′′-hydroxyneomycin C + H2O = 6′′′-deamino-6′′′-hydroxyneomycin C + acetate
Other name(s): neoL (gene name)
Systematic name: 2′′′-acetyl-6′′′-hydroxyneomycin C hydrolase (acetate-forming)
Comments: Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. The enzyme from the bacterium Streptomyces fradiae also catalyses EC 3.5.1.112, 2′-N-acetylparomamine deacetylase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Yokoyama, K., Yamamoto, Y., Kudo, F. and Eguchi, T. Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis. ChemBioChem. 9 (2008) 865–869. [PMID: 18311744]
[EC 3.5.1.113 created 2012]
 
 


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