2′′′-acetyl-6′′′-deamino-6′′′-hydroxyneomycin C + H2O = 6′′′-deamino-6′′′-hydroxyneomycin C + acetate
neoL (gene name)
2′′′-acetyl-6′′′-hydroxyneomycin C hydrolase (acetate-forming)
Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. The enzyme from the bacterium Streptomyces fradiae also catalyses EC 220.127.116.11, 2′-N-acetylparomamine deacetylase.
Yokoyama, K., Yamamoto, Y., Kudo, F. and Eguchi, T. Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis. ChemBioChem.9 (2008) 865–869. [DOI] [PMID: 18311744]