The Enzyme Database

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Accepted name: 2′-N-acetylparomamine deacetylase
Reaction: 2′-N-acetylparomamine + H2O = paromamine + acetate
For diagram of paromamine biosynthesis, click here
Glossary: paromamine = (1R)-O4-(2-amino-2-deoxy-α-D-glucopyranosyl)-2-deoxy-streptamine
Other name(s): btrD (gene name); neoL (gene name); kanN (gene name)
Systematic name: 2′-N-acetylparomamine hydrolase (acetate-forming)
Comments: Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. The enzyme from the bacterium Streptomyces fradiae can also accept 2′′′-acetyl-6′′′-hydroxyneomycin C as substrate, cf. EC, 2′′′-acetyl-6′′′-hydroxyneomycin C deacetylase [2].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Truman, A.W., Huang, F., Llewellyn, N.M. and Spencer, J.B. Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin. Angew. Chem. Int. Ed. Engl. 46 (2007) 1462–1464. [PMID: 17226887]
2.  Yokoyama, K., Yamamoto, Y., Kudo, F. and Eguchi, T. Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis. ChemBioChem. 9 (2008) 865–869. [PMID: 18311744]
[EC created 2012]

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