| EC |
3.4.24.86 |
| Accepted name: |
ADAM 17 endopeptidase |
| Reaction: |
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala┼Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumour necrosis factor α (TNFα). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains |
| Other name(s): |
tumor necrosis factor α-converting enzyme; TACE |
| Comments: |
In peptidase family M12. In vivo, the cleavage of tumour necrosis factor α precursor releases the soluble, 17-kDa TNFα, which induces inflammation. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 151769-16-3 |
| References: |
| 1. |
Black, R.A. Tumor necrosis factor-α converting enzyme. Int. J. Biochem. Cell Biol. 34 (2002) 1–5. [DOI] [PMID: 11733179] |
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| [EC 3.4.24.86 created 2003] |
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