The Enzyme Database

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EC 3.4.24.84     
Accepted name: Ste24 endopeptidase
Reaction: The peptide bond hydrolysed can be designated -C┼aaX in which C is an S-isoprenylated cysteine residue, a is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids
Comments: Type example of peptidase family M48. One of two enzymes that can catalyse this processing step for mating a-factor in yeast. Subsequently, the S-isoprenylated cysteine residue that forms the new C-terminus is methyl-esterified and forms a hydrophobic membrane-anchor.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, SWISSPROT, CAS registry number: 148463-92-7
References:
1.  Tam, A., Schmidt, W.K. and Michaelis, S. The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor. J. Biol. Chem. 276 (2001) 46798–46806. [PMID: 11581258]
[EC 3.4.24.84 created 2003]
 
 


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