ExplorEnz: EC 3.4.24.82

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3.4.24.82

Accepted name:

ADAMTS-4 endopeptidase

Reaction:

Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu³⁷³┼Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan

Other name(s):

aggrecanase-1

Comments:

In peptidase family M12. Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix.

Links to other databases:

BRENDA, EXPASY, KEGG, METACYC, MEROPS, PDB, SWISSPROT, CAS registry number: 147172-61-0

References:

Westling, J., Fosang, A.J., Last, K., Thompson, V.P., Tomkinson, K.N., Hebert, T., McDonagh, T., Collins-Racie, L.A., LaVallie, E.R., Morris, E.A. and Sandy, J.D. ADAMTS4 cleaves at the aggrecanase site (Glu³⁷³-Ala³⁷⁴) and secondarily at the matrix metalloproteinase site (Asn³⁴¹-Phe³⁴²) in the aggrecan interglobular domain. J. Biol. Chem. 277 (2002) 16059–16066. [PMID: 11854269]

[EC 3.4.24.82 created 2003]