The Enzyme Database

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Accepted name: ADAM10 endopeptidase
Reaction: Endopeptidase of broad specificity
Other name(s): Kuzbanian protein; myelin-associated disintegrin metalloproteinase
Comments: In peptidase family M12. Partially responsible for the "α-secretase" activity in brain that degrades the potentially harmful β-amyloid peptide. Work with ADAM10-deficient mice supports a role in Notch signalling.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, SWISSPROT, CAS registry number: 193099-09-1
1.  Gutwein, P., Mechtersheimer, S., Riedle, S., Stoeck, A., Gast, D., Joumaa, S., Zentgraf, H., Fogel, M. and Altevogt, D.P. ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. FASEB J. 17 (2003) 292–294. [PMID: 12475894]
[EC created 2003]

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