Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37┼Leu. Other bonds hydrolysed include Gly35┼Ile in the propeptide of collagenase 3, and Asn341┼Phe, Asp441┼Leu and Gln354┼Thr in the aggrecan interglobular domain
matrix metalloproteinase 14
In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.