| EC |
3.4.24.80 |
| Accepted name: |
membrane-type matrix metalloproteinase-1 |
| Reaction: |
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37┼Leu. Other bonds hydrolysed include Gly35┼Ile in the propeptide of collagenase 3, and Asn341┼Phe, Asp441┼Leu and Gln354┼Thr in the aggrecan interglobular domain |
| Other name(s): |
matrix metalloproteinase 14 |
| Comments: |
In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 161384-17-4 |
| References: |
| 1. |
Itoh, Y., Takamura, A., Ito, N., Maru, Y., Sato, H., Suenaga, N., Aoki, T. and Seiki, M. Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion. EMBO J. 20 (2001) 4782–4793. [DOI] [PMID: 11532942] |
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| [EC 3.4.24.80 created 2003] |
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