EC |
3.4.24.75 |
Accepted name: |
lysostaphin |
Reaction: |
Hydrolysis of the -Gly┼Gly- bond in the pentaglycine inter-peptide link joining staphylococcal cell wall peptidoglycans |
Other name(s): |
glycyl-glycine endopeptidase |
Comments: |
A zinc-dependent, 25-kDa endopeptidase from Staphylococcus simulans. Lyses cells of S. aureus, in particular, by its action on the cross-bridges of the cell wall. Type example of peptidase family M23. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9011-93-2 |
References: |
1. |
Recsei, P.A., Gruss, A.D. and Novick, R.P. Cloning, sequence, and expression of the lysostaphin gene from Staphylococcus simulans. Proc. Natl. Acad. Sci. USA 84 (1987) 1127–1131. [DOI] [PMID: 3547405] |
2. |
Baba, T. and Schneewind, O. Target cell specificity of a bacteriocin molecule: A C-terminal signal directs lysostaphin to the cell wall of Staphylococcus aureus. EMBO J. 15 (1996) 4789–4797. [PMID: 8890152] |
3. |
Thumm, G. and Götz, F. Studies on prolysostaphin processing and characterization of the lysostaphin immunity factor (Lif) of Staphylococcus simulans biovar staphylolyticus. Mol. Microbiol. 23 (1997) 1251–1265. [DOI] [PMID: 9106216] |
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[EC 3.4.24.75 created 1997] |
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