The Enzyme Database

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EC 3.4.24.73     
Accepted name: jararhagin
Reaction: Hydrolysis of -His10┼Leu-, -Ala14┼Leu-, -Tyr16┼Leu-and -Phe24┼Phe- bonds in insulin B chain
Other name(s): HF2-proteinase; JF1
Comments: Hemorrhagic endopeptidase from the venom of the jararaca snake (Bothrops jararaca). The 52-kDa enzyme contains a disintegrin domain [3]. In peptidase family M12 (astacin family)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 160477-79-2
References:
1.  Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca. In: Ohsaka, A., Hayashi, K. and Sawai, Y. (Eds), Animal, Plant and Microbial Toxins, Plenum Press, New York, 1976, pp. 111–121.
2.  Assakura, M.T., Reichl, A.P. and Mandelbaum, F.R. Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca). Toxicon 24 (1986) 943–946. [PMID: 3810664]
3.  Paine, M.J.I., Desmond, H.P., Theakston, R.D.G. and Crampton, J.M. Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family. J. Biol. Chem. 267 (1992) 22869–22876. [PMID: 1385408]
[EC 3.4.24.73 created 1996]
 
 


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