ExplorEnz: EC 3.4.24.71

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3.4.24.71

Accepted name:

endothelin-converting enzyme 1

Reaction:

Hydrolysis of the -Trp²¹┼Val- bond in big endothelin to form endothelin 1

Other name(s):

endothelin-converting enzyme; ECE-1

Comments:

A phosphoramidon-sensitive metalloendopeptidase in peptidase family M13 (neprilysin family). An integral membrane protein predominantly of endothelial cells, which generates the potent vasoconstrictor endothelin 1 from its inactive precursor

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 138238-81-0

References:

1.	Takahashi, M., Matsushita, Y., Iijima, Y. and Tanzawa, K. Purification and characterization of endothelin-converting enzyme from rat lung. J. Biol. Chem. 268 (1993) 21394–21398. [PMID: 8407980]
2.	Shimada, K., Takahashi, M. and Tanzawa, K. Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells. J. Biol. Chem. 269 (1994) 18275–18278. [PMID: 8034569]
3.	Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., DeWit, D. and Yanagisawa, M. ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 78 (1994) 473–485. [DOI] [PMID: 8062389]

[EC 3.4.24.71 created 1996]