The Enzyme Database

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EC 3.4.24.6     
Accepted name: leucolysin
Reaction: Cleavage of Phe1┼Val, His5┼Leu, Ala14┼Leu, Gly20┼Glu, Gly23┼Phe and Phe24┼Phe bonds in insulin B chain as well as N-blocked dipeptides
Other name(s): Leucostoma neutral proteinase; Leucostoma peptidase A
Comments: From the venom of the western cottonmouth moccasin snake (Agkistrodon piscivorus leucostoma).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 72561-03-6
References:
1.  Wagner, F.W., Spiekerman, A.M. and Prescott, J.M. Leucostoma peptidase A. Isolation and physical properties. J. Biol. Chem. 243 (1968) 4486–4493. [PMID: 5684005]
2.  Spiekerman, A.M., Fredericks, K.K., Wagner, F.W. and Prescott, J.M. Leucostoma peptidase A: a metalloprotease from snake venom. Biochim. Biophys. Acta 293 (1973) 464–475. [PMID: 4711816]
[EC 3.4.24.6 created 1978]
 
 


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