| EC |
3.4.24.59 |
| Accepted name: |
mitochondrial intermediate peptidase |
| Reaction: |
Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion |
| Other name(s): |
mitochondrial intermediate precursor-processing proteinase; MIP |
| Comments: |
A homologue of thimet oligopeptidase. Natural substrates are precursor proteins that have already been processed by mitochondrial processing peptidase. In peptidase family M3 (thimet oligopeptidase family) |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 136447-30-8 |
| References: |
| 1. |
Isaya, G., Kalousek, F. and Rosenberg, L.E. Amino-terminal octapeptides function as recognition signals for the mitochondrial intermediate peptidase. J. Biol. Chem. 267 (1992) 7904–7910. [PMID: 1560019] |
| 2. |
Isaya, G., Kalousek, F. and Rosenberg, L.E. Sequence analysis of rat mitochondrial intermediate peptidase: similarity to zinc metallopeptidases and to a putative yeast homologue. Proc. Natl. Acad. Sci. USA 89 (1992) 8317–8321. [DOI] [PMID: 1518864] |
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| [EC 3.4.24.59 created 1993] |
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