The Enzyme Database

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EC 3.4.24.58     
Accepted name: russellysin
Reaction: Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg┼ bonds. Has no action on insulin B chain
Other name(s): Russell’s viper venom factor X activator, RVV-X; blood-coagulation factor X activating enzyme; metalloproteinase RVV-x; Vipera russelli proteinase; Russell’s viper blood coagulation factor X activator; RVV-V
Comments: This enzyme from the venom of Russell’s viper (Vipera russelli) of 79 kDa comprises a heavy (59 kDa) and a heterogeneous light (18-21 kDa) chain. Contains Ca2+ and Zn2+. The heavy chain contains the zinc-binding endopeptidase domain and a disintegrin. In peptidase family M12 (astacin family)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 79393-92-3
References:
1.  Furie, B.C. and Furie, B. Coagulant protein of Russell's viper venom. Methods Enzymol. 45 (1976) 191–205. [PMID: 1011991]
2.  Lindquist, P.A., Fujikawa, K. and Davie, E.W. Activation of bovine factor IX (Christmas factor) by factor XIa (activated plasma thromboplastin antecent) and a protease from Russell's viper venom. J. Biol. Chem. 253 (1978) 1902–1909. [PMID: 632245]
3.  Takeya, H., Nishida, S., Miyata, T., Kawada, S., Saisaka, Y., Morita, T. and Iwanaga, S. Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains. J. Biol. Chem. 267 (1992) 14109–14117. [PMID: 1629211]
[EC 3.4.24.58 created 1993]
 
 


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