The Enzyme Database

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EC 3.4.24.57     
Accepted name: O-sialoglycoprotein endopeptidase
Reaction: Hydrolysis of O-sialoglycoproteins; cleaves -Arg31┼Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated
Other name(s): glycoprotease; glycophorin A proteinase; glycoproteinase; sialoglycoprotease; sialoglycoproteinase
Comments: An enzyme secreted by the bacterium Pasteurella haemolytica. Inhibited by EDTA (100 mM) and 1,10-phenanthroline. Type example of peptidase family M22
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 129430-53-1
References:
1.  Abdullah, K.M., Lo, R.Y.C. and Mellors, A. Cloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene. J. Bacteriol. 173 (1991) 5597–5603. [PMID: 1885539]
2.  Abdullah, K.M., Udoh, E.A., Shewen, P.E. and Mellors, A. A neutral glycoprotease of Pasteurella haemolytica A1 specifically cleaves O-sialoglycoproteins. Infect. Immun. 60 (1992) 56–62. [PMID: 1729196]
3.  Sutherland, D.R., Abdullah, K.M., Cyopick, P. and Mellors, A. Cleavage of the cell-surface O-sialoglycoproteins CD34, CD 43, CD 44, and CD45 by a novel glycoprotease from Pasteurella haemolytica. J. Immunol. 148 (1992) 1458–1464. [PMID: 1371528]
[EC 3.4.24.57 created 1993]
 
 


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