The Enzyme Database

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EC 3.4.24.50     
Accepted name: bothrolysin
Reaction: Cleavage of Gln4┼His, Ser9┼His and Ala14┼Leu of insulin B chain and Pro┼Phe of angiotensin I
Other name(s): Bothrops metalloendopeptidase J; J protease
Comments: A 22.5 kDa endopeptidase from the venom of the jararaca snake (Bothrops jararaca), insensitive to phosphoramidon at 0.5 mM. In peptidase family M12 (astacin family)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 443890-65-1
References:
1.  Tanizaki, M.M., Zingali, R.B., Kawazaki, H., Imajoh, S., Yamazaki, S. and Suzuki, K. Purification and some characteristics of a zinc metalloprotease from the venom of Bothrops jararaca (jararaca). Toxicon 27 (1989) 747–755. [PMID: 2781574]
[EC 3.4.24.50 created 1992]
 
 


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