The Enzyme Database

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EC 3.4.24.47     
Accepted name: horrilysin
Reaction: Cleavage of only the single bond Ala14┼Leu in the insulin B chain, Ser12┼Leu in the A chain, and Ile┼Gly, Pro┼Ala, and Ser┼Trp in melittin
Other name(s): Crotalus horridus metalloendopeptidase; hemorrhagic proteinase IV; Crotalus horridus horridus venom hemorrhagic proteinase
Comments: A 56 kDa hemorrhagic endopeptidase from the venom of the timber rattlesnake (Crotalus horridus horridus) that cleaves basement membrane, hide powder and fibrinogen.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 84056-81-5
References:
1.  Civello, D.J., Duong, H.L. and Geren, C.R. Isolation and characterization of a hemorrhagic proteinase from timber rattlesnake venom. Biochemistry 22 (1983) 749–755. [PMID: 6340728]
2.  Civello, D.J., Moran, J.B. and Geren, C.R. Substrate specificity of a hemorrhagic proteinase from timber rattlesnake venom. Biochemistry 22 (1983) 755–762. [PMID: 6340729]
[EC 3.4.24.47 created 1992]
 
 


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