The Enzyme Database

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EC 3.4.24.45     
Accepted name: atrolysin F
Reaction: Cleavage of Val2┼Asn, Gln4┼His, Leu6┼Cys, His10┼Leu, Ala14┼Leu and Tyr16┼Leu bonds in insulin B chain
Other name(s): Crotalus atrox metalloendopeptidase; hemorrhagic toxin f; Crotalus atrox metalloendopeptidase f
Comments: A 64 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests the γ chain of fibrinogen. Immunologically distinct from EC 3.4.24.1, atrolysin A.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 172306-52-4
References:
1.  Nikai, T., Mori, N., Kishida, M., Sugihara, H. and Tu, A.T. Isolation and biochemical characterization of hemorrhagic toxin f from the venom of Crotalus atrox (western diamondback rattlesnake). Arch. Biochem. Biophys. 231 (1984) 309–319. [PMID: 6375570]
[EC 3.4.24.45 created 1992]
 
 


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