| EC |
3.4.24.41 |
| Accepted name: |
atrolysin B |
| Reaction: |
Cleavage of His5┼Leu, His10┼Leu, Ala14┼Leu, Tyr16┼Leu and Gly23┼Phe of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves ┼Ser bonds in glucagon |
| Other name(s): |
Crotalus atrox metalloendopeptidase b; hemorrhagic toxin b; Ht-b |
| Comments: |
From the venom of the western diamondback rattlesnake (Crotalus atrox). In peptidase family M12 (astacin family) |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 172306-48-8 |
| References: |
| 1. |
Bjarnason, J.B. and Tu, A.T. Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e. Biochemistry 17 (1978) 3395–3404. [PMID: 210790] |
| 2. |
Bjarnason, J.B., Hamilton, D. and Fox, J.W. Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom. Biol. Chem. Hoppe-Seyler 369 (1988) 121–129. [PMID: 3060135] |
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| [EC 3.4.24.41 created 1992] |
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