The Enzyme Database

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EC 3.4.24.41     
Accepted name: atrolysin B
Reaction: Cleavage of His5┼Leu, His10┼Leu, Ala14┼Leu, Tyr16┼Leu and Gly23┼Phe of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves ┼Ser bonds in glucagon
Other name(s): Crotalus atrox metalloendopeptidase b; hemorrhagic toxin b; Ht-b
Comments: From the venom of the western diamondback rattlesnake (Crotalus atrox). In peptidase family M12 (astacin family)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 172306-48-8
References:
1.  Bjarnason, J.B. and Tu, A.T. Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e. Biochemistry 17 (1978) 3395–3404. [PMID: 210790]
2.  Bjarnason, J.B., Hamilton, D. and Fox, J.W. Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom. Biol. Chem. Hoppe-Seyler 369 (1988) 121–129. [PMID: 3060135]
[EC 3.4.24.41 created 1992]
 
 


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