| EC |
3.4.24.19 |
| Accepted name: |
procollagen C-endopeptidase |
| Reaction: |
Cleavage of the C-terminal propeptide at Ala┼Asp in type I and II procollagens and at Arg┼Asp in type III |
| Other name(s): |
procollagen C-terminal proteinase; carboxyprocollagen peptidase; procollagen C-terminal peptidase; procollagen C-proteinase; procollagen carboxypeptidase; procollagen carboxy-terminal proteinase; procollagen peptidase |
| Comments: |
A 100 kDa endopeptidase the activity of which is increased by Ca2+ and by an enhancer glycoprotein. In peptidase family M12 (astacin family) |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 68651-95-6 |
| References: |
| 1. |
Hojima, Y., van der Rest, M. and Prockop, D.J. Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization. J. Biol. Chem. 260 (1985) 15996–16003. [PMID: 3905801] |
| 2. |
Kessler, E. and Adar, R. Type I procollagen C-proteinase from mouse fibroblasts. Purification and demonstration of a 55-kDa enhancer glycoprotein. Eur. J. Biochem. 186 (1989) 115–121. [PMID: 2689170] |
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| [EC 3.4.24.19 created 1992] |
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