The Enzyme Database

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EC 3.4.24.12     
Accepted name: envelysin
Reaction: Hydrolysis of proteins of the fertilization envelope and dimethylcasein
Other name(s): sea-urchin-hatching proteinase; hatching enzyme; chorionase; chorion-digesting proteinase; chymostrypsin; sea urchin embryo hatching enzyme
Comments: A glycoprotein from various members of the class Echinoidea. Extracellular enzyme requiring Ca2+. In peptidase family M10 (interstitial collagenase family)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 50812-13-0
References:
1.  Barrett, D. and Edwards, B.F. Hatching enzyme of the sea urchin Strongylocentrotus purpuratus. Methods Enzymol. 45 (1976) 354–373. [PMID: 1012003]
2.  Lepage, T. and Gache, C. Purification and characterization of the sea urchin embryo hatching enzyme. J. Biol. Chem. 264 (1989) 4787–4793. [PMID: 2925668]
3.  Lepage, T. and Gache, C. Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo. EMBO J. 9 (1990) 3003–3012. [PMID: 2167841]
4.  Nomura, K., Tanaka, H., Kikkawa, Y., Yamaguchi, M. and Suzuki, N. The specificity of sea urchin hatching enzyme (envelysin) places it in the mammalian matrix metalloproteinase family. Biochemistry 30 (1991) 6115–6123. [PMID: 1711895]
[EC 3.4.24.12 created 1978]
 
 


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