| EC |
3.4.23.45 |
| Accepted name: |
memapsin 1 |
| Reaction: |
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu┼Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer'''s amyloid precursor protein |
| Other name(s): |
β-secretase; β-site Alzheimer's amyloid precursor protein cleaving enzyme 2 (BACE2); ASP1; Down region aspartic protease |
| Comments: |
Can cleave β-amyloid precursor protein to form the amyloidogenic β-peptide that is implicated in the pathology of Alzheimer's disease, but is not significantly expressed in human brain. In peptidase family A1, but is atypical in containing a C-terminal membrane-spanning domain. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 447457-31-0 |
| References: |
| 1. |
Turner, R.T., Loy, J.A., Nguyen, C., Devasamudram, T., Ghosh, A.K., Koelsch, G. and Tang, J. Specificity of memapsin 1 and its implications on the design of memapsin 2 (β-secretase) inhibitor selectivity. Biochemistry 41 (2002) 8742–8746. [DOI] [PMID: 12093293] |
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| [EC 3.4.23.45 created 2003] |
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