| EC |
3.4.23.36 |
| Accepted name: |
signal peptidase II |
| Reaction: |
Release of signal peptides from bacterial membrane prolipoproteins including murein prolipoprotein. Hydrolyses -Xaa-Yaa-Zaa┼(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral sidechains |
| Other name(s): |
premurein-leader peptidase; prolipoprotein signal peptidase; leader peptidase II; premurein leader proteinase |
| Comments: |
An 18-kDa enzyme present in bacterial inner membranes. Inhibited by pepstatin and the antibiotic globomycin. Type example of peptidase family A8. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 171715-14-3 |
| References: |
| 1. |
Dev, I.K. and Ray, P.H. Signal peptidases and signal peptide hydrolases. J. Bioenerg. Biomembr. 22 (1990) 271–290. [PMID: 2202720] |
| 2. |
Zhao, X.-J. and Wu, H.C. Nucleotide sequence of the Staphylococcus aureus signal peptidase II (lsp) gene. FEBS Lett. 299 (1992) 80–84. [DOI] [PMID: 1544479] |
| 3. |
Sankaran, K. and Wu, H.C. Bacterial prolipoprotein signal peptidase. Methods Enzymol. 248 (1995) 169–180. [PMID: 7674920] |
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| [EC 3.4.23.36 created 1984 as EC 3.4.99.35, transferred 1995 to EC 3.4.23.36] |
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