The Enzyme Database

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EC 3.4.23.15     
Accepted name: renin
Reaction: Cleavage of Leu┼ bond in angiotensinogen to generate angiotensin I
Other name(s): angiotensin-forming enzyme; angiotensinogenase
Comments: Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9015-94-5
References:
1.  Inagami, T. and Murakami, K. Pure renin. Isolation from hog kidney and characterization. J. Biol. Chem. 252 (1977) 2978–2983. [PMID: 16012]
2.  Slater, E.E. Renin. Methods Enzymol. 80 (1981) 427–442. [PMID: 7043197]
3.  Inagami, T. Structure and function of renin. J. Hypertension 2) (1989) S3–S8. [PMID: 2666611]
4.  Sielecki, A.R., Hayakawa, K., Fujinaga, M., Murphy, M.E.P., Fraser, M., Muir, A.K., Carilli, C.T., Lewicki, J.A., Baxter, J.D. and James, M.N.G. Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 Å resolution. Science 243 (1989) 1346–1351. [PMID: 2493678]
[EC 3.4.23.15 created 1961 as EC 3.4.4.15, transferred 1972 to EC 3.4.99.19, transferred 1981 to EC 3.4.23.15]
 
 


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