ExplorEnz: EC 3.4.22.34

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3.4.22.34

Accepted name:

legumain

Reaction:

Hydrolysis of proteins and small molecule substrates at -Asn┼Xaa- bonds

Other name(s):

asparaginyl endopeptidase; citvac; proteinase B (ambiguous); hemoglobinase (ambiguous); PRSC1 gene product (Homo sapiens); vicilin peptidohydrolase; bean endopeptidase

Comments:

Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. Not inhibited by compound E-64. Type example of peptidase family C13

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 149371-18-6

References:

1.	Hara-Nishimura, I. Asparaginyl endopeptidase. In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Ed.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, pp. 746–749.
2.	Dalton, J.P. and Brindley, P.J. Schistosome legumain. In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Ed.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, pp. 749–754.
3.	Chen, J.-M., Rawlings, N.D., Stevens, R.A.E. and Barrett, A.J. Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases. FEBS Lett. 441 (1998) 361–365. [DOI] [PMID: 9891971]

[EC 3.4.22.34 created 1992, modified 2000]