The Enzyme Database

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EC 3.4.22.34     
Accepted name: legumain
Reaction: Hydrolysis of proteins and small molecule substrates at -Asn┼Xaa- bonds
Other name(s): asparaginyl endopeptidase; citvac; proteinase B (ambiguous); hemoglobinase (ambiguous); PRSC1 gene product (Homo sapiens); vicilin peptidohydrolase; bean endopeptidase; vicilin peptidohydrolase
Comments: Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. Not inhibited by compound E-64. Type example of peptidase family C13
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 149371-18-6
References:
1.  Hara-Nishimura, I. Asparaginyl endopeptidase. In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, pp. 746–749.
2.  Dalton, J.P. and Brindley, P.J. Schistosome legumain. In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, pp. 749–754.
3.  Chen, J.-M., Rawlings, N.D., Stevens, R.A.E. and Barrett, A.J. Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases. FEBS Lett. 441 (1998) 361–365. [PMID: 9891971]
[EC 3.4.22.34 created 1992, modified 2000]
 
 


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