| EC |
3.4.22.16 |
| Accepted name: |
cathepsin H |
| Reaction: |
Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg┼ bonds) as well as an endopeptidase |
| Other name(s): |
cathepsin B3; benzoylarginine-naphthylamide (BANA) hydrolase (obsolete); cathepsin Ba; aleurain; N-benzoylarginine-β-naphthylamide hydrolase |
| Comments: |
Present in lysosomes of mammalian cells. In peptidase family C1 (papain family) |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 60748-73-4 |
| References: |
| 1. |
Barrett, A.J. and Kirschke, H. Cathepsin B, cathepsin H and cathepsin L. Methods Enzymol. 80 (1981) 535–561. [PMID: 7043200] |
| 2. |
Brömme, D., Bescherer, K., Kirschke, H. and Fittkau, S. Enzyme-substrate interactions in the hydrolysis of peptides by cathepsins B and H from rat liver. Biochem. J. 245 (1987) 381–385. [PMID: 3663163] |
| 3. |
Fuchs, R., Machleidt, W. and Gassen, H.G. Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H. Biol. Chem. Hoppe-Seyler 369 (1988) 469–475. [PMID: 2849458] |
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| [EC 3.4.22.16 created 1981, modified 1989] |
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