The Enzyme Database

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EC 3.4.21.46     
Accepted name: complement factor D
Reaction: Selective cleavage of Arg┼Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor
Other name(s): C3 proactivator convertase; properdin factor D esterase; factor D; factor D (complement)
Comments: A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C1s. In peptidase family S1 (trypsin family)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 37213-56-2
References:
1.  Reid, K.B.M., Johnson, D.M.A., Gagnon, J. and Prohaska, R. Preparation of human factor D of the alternative pathway of complement. Methods Enzymol. 80 (1981) 134–143. [PMID: 6918766]
2.  Müller-Eberhard, H.J. Molecular organization and function of the complement system. Annu. Rev. Biochem. 57 (1988) 321–347. [PMID: 3052276]
[EC 3.4.21.46 created 1981]
 
 


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