The Enzyme Database

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EC 3.4.21.45     
Accepted name: complement factor I
Reaction: Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage
Other name(s): complement component C3b inactivator; C3b inactivator; C3b/C4b inactivator; C3bINA; complement C3b/C4b inactivator; complement C4b inactivator; conglutinogen-activating factor C; complement C3b inactivator; factor I; complement C4bi
Comments: Cleavage of complement subcomponent C3b requires its binding to cofactor factor H or complement receptor CR1; cleavage of iC3b requires complement receptor CR1; cleavage of C4b requires C4b-binding protein. In peptidase family S1 (trypsin family)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 80295-66-5
References:
1.  Nagasawa, S., Ichihara, C. and Stroud, R.M. Cleavage of C4b by C3b inactivator: production of a nicked form from C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator. J. Immunol. 125 (1980) 578–582. [PMID: 7391570]
2.  Crossley, L.G. C3b inactivator and β1H. Methods Enzymol. 80 (1981) 112–124. [PMID: 6210825]
3.  Müller-Eberhard, H.J. Molecular organization and function of the complement system. Annu. Rev. Biochem. 57 (1988) 321–347. [PMID: 3052276]
[EC 3.4.21.45 created 1981]
 
 


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