The Enzyme Database

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EC 3.4.21.38     
Accepted name: coagulation factor XIIa
Reaction: Selective cleavage of Arg┼Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa
Other name(s): Hageman factor (activated); blood-coagulation factor XIIf; activated β blood-coagulation factor XII; prealbumin activator; Hageman factor β-fragment; Hageman factor fragment HFf; blood-coagulation factor XIIaβ; prekallikrein activator; kallikreinogen activator
Comments: Also activates plasminogen and plasma prokallikrein. Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa. In peptidase family S1 (trypsin family)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 75216-42-1
References:
1.  Fujikawa, K. and Davie, E.W. Human factor XII (Hageman factor). Methods Enzymol. 80 (1981) 198–211. [PMID: 6918768]
2.  Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates. Biochemistry 23 (1984) 644–650. [PMID: 6370301]
3.  Que, B.G. and Davie, E.W. Characterization of a cDNA coding for human factor XII (Hageman factor). Biochemistry 25 (1986) 1525–1528. [PMID: 3011063]
4.  Fujikawa, K. Bovine Hageman factor and its fragments. Methods Enzymol. 163 (1988) 54–68. [PMID: 3237089]
5.  Silverberg, M. and Kaplan, A.P. Human Hageman factor and its fragments. Methods Enzymol. 163 (1988) 68–80. [PMID: 3237092]
[EC 3.4.21.38 created 1981]
 
 


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