The Enzyme Database

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Accepted name: plasma kallikrein
Reaction: Selective cleavage of some Arg┼ and Lys┼ bonds, including Lys┼Arg and Arg┼Ser in (human) kininogen to release bradykinin
Other name(s): serum kallikrein; kininogenin; kallikrein I; kallikrein II; kininogenase; kallikrein; callicrein; glumorin; padreatin; padutin; kallidinogenase; bradykininogenase; panceatic kallikrein; onokrein P; dilminal D; depot-Padutin; urokallikrein; urinary kallikrein
Comments: Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. Activates coagulation factors XII, VII and plasminogen. Selective for Arg > Lys in P1, in small molecule substrates.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 410538-33-9
1.  Heimark, R.L. and Davie, E.W. Bovine and human plasma prekallikrein. Methods Enzymol. 80 (1981) 157–172. [PMID: 6918767]
2.  McRae, B.J., Kurachi, K., Heimark, R.L., Fujikawa, K., Davie, E.W. and Powers, J.C. Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates. Biochemistry 20 (1981) 7196–7206. [PMID: 6976185]
3.  Silverberg, M. and Kaplan, A.P. Prekallikrein. Methods Enzymol. 163 (1988) 85–95. [PMID: 3237096]
4.  Seidah, N.G., Ladenheim, R., Mbikay, M., Hamelin, J., Lutfalla, G., Rougeon, F., Lazure, C. and Chrétien, M. The cDNA structure of rat plasma kallikrein. DNA 8 (1989) 563–574. [PMID: 2598771]
5.  Tsuda, Y., Teno, N., Okada, Y., Wanaka, K., Bohgaki, M., Hijikata-Okunomiya, A., Okamoto, U., Naito, T. and Okamoto, S. Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein. Chem. Pharm. Bull. 37 (1989) 3108–3111. [PMID: 2534361]
[EC created 1965 as EC, transferred 1972 to, part transferred 1981 to EC]

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