The Enzyme Database

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EC 3.4.17.3     
Accepted name: lysine carboxypeptidase
Reaction: Release of a C-terminal basic amino acid, preferentially lysine
Other name(s): carboxypeptidase N; arginine carboxypeptidase; kininase I; anaphylatoxin inactivator; plasma carboxypeptidase B; creatine kinase conversion factor; bradykinase; kininase Ia; hippuryllysine hydrolase; bradykinin-decomposing enzyme; protaminase; CPase N; creatinine kinase convertase; peptidyl-L-lysine(-L-arginine) hydrolase; CPN
Comments: A zinc enzyme found in plasma. Inactivates bradykinin and anaphylatoxins in blood plasma. In peptidase family M14 (carboxypeptidase A family).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9013-89-2
References:
1.  Plummer, T.H., Jr. and Erdös, E.G. Human plasma carboxypeptidase N. Methods Enzymol. 80 (1981) 442–449. [PMID: 7341915]
2.  Levin, Y., Skidgel, R.A. and Erdös, E.G. Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase I). Proc. Natl. Acad. Sci. USA 79 (1982) 4618–4622. [PMID: 6750606]
3.  Skidgel, R.A. Basic carboxypeptidases: regulators of peptide hormone activity. Trends Pharmacol. Sci. 9 (1988) 301–303. [PMID: 3074547]
[EC 3.4.17.3 created 1972 as EC 3.4.12.7, transferred 1978 to EC 3.4.17.3, modified 1989]
 
 


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