The Enzyme Database

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EC 3.4.14.10     
Accepted name: tripeptidyl-peptidase II
Reaction: Release of an N-terminal tripeptide from a polypeptide
Other name(s): tripeptidyl aminopeptidase; tripeptidyl peptidase; tripeptidyl aminopeptidase II; tripeptidyl peptidase II; TPP
Comments: A cytosolic enzyme in peptidase family S8 (subtilisin family). Active at neutral pH. Inhibited by diisopropyl fluorophosphate. Formerly included in EC 3.4.14.8
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 101149-94-4
References:
1.  Bålöw, R.M., Ragnarsson, U. and Zetterqvist, Ö. Tripeptidyl aminopeptidase in the extralysosomal fraction of rat liver. J. Biol. Chem. 258 (1983) 11622–11628. [PMID: 6352701]
2.  Bålöw, R.M., Tomkinson, B., Ragnarsson, U. and Zetterqvist, Ö. Purification, substrate specificity, and classification of tripeptidyl peptidase II. J. Biol. Chem. 261 (1986) 2409–2417. [PMID: 3511062]
3.  Tomkinson, B. and Zetterqvist, Ö. Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin. Biochem. J. 267 (1990) 149–154. [PMID: 1691635]
[EC 3.4.14.10 created 1992 (part of EC 3.4.14.8 created 1989, incorporated 1992)]
 
 


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