The Enzyme Database

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EC 3.2.2.8     
Accepted name: ribosylpyrimidine nucleosidase
Reaction: a pyrimidine nucleoside + H2O = D-ribose + a pyrimidine base
Other name(s): N-ribosylpyrimidine nucleosidase; pyrimidine nucleosidase; N-ribosylpyrimidine ribohydrolase; pyrimidine nucleoside hydrolase; RihB; YeiK; nucleoside ribohydrolase
Systematic name: pyrimidine-nucleoside ribohydrolase
Comments: Also hydrolyses purine D-ribonucleosides, but much more slowly. 2′-, 3′- and 5′-deoxynucleosides are not substrates [3].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37288-60-1
References:
1.  Terada, M., Tatibana, M. and Hayaishi, O. Preparation and properties of nucleoside hydrolase from Pseudomonas fluorescens. J. Biol. Chem. 242 (1967) 5578–5585. [PMID: 12325375]
2.  Petersen, C. and Møller, L.B. The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation. J. Biol. Chem. 276 (2001) 884–894. [PMID: 11027694]
3.  Giabbai, B. and Degano, M. Cloning, purification, crystallization and X-ray analysis of the Escherichia coli pyrimidine nucleoside hydrolase YeiK. Acta Crystallogr. D Biol. Crystallogr. 60 (2004) 524–527. [PMID: 14993681]
4.  Giabbai, B. and Degano, M. Crystal structure to 1.7 Å of the Escherichia coli pyrimidine nucleoside hydrolase YeiK, a novel candidate for cancer gene therapy. Structure 12 (2004) 739–749. [PMID: 15130467]
[EC 3.2.2.8 created 1972]
 
 


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