| EC |
3.2.2.29 |
| Accepted name: |
thymine-DNA glycosylase |
| Reaction: |
Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine. |
| Other name(s): |
mismatch-specific thymine-DNA glycosylase; mismatch-specific thymine-DNA N-glycosylase; hTDG; hsTDG; TDG; thymine DNA glycosylase; G/T glycosylase; uracil/thymine DNA glycosylase; T:G mismatch-specific thymidine-DNA glycosylase; G:T mismatch-specific thymine DNA-glycosylase |
| Systematic name: |
thymine-DNA deoxyribohydrolase (thymine-releasing) |
| Comments: |
Thymine-DNA glycosylase is part of the DNA-repair machinery. Thymine removal is fastest when it is from a G/T mismatch with a 5′-flanking C/G pair. The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T [3]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Waters, T.R. and Swann, P.F. Thymine-DNA glycosylase and G to A transition mutations at CpG sites. Mutat. Res. 462 (2000) 137–147. [DOI] [PMID: 10767625] |
| 2. |
Neddermann, P. and Jiricny, J. The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells. J. Biol. Chem. 268 (1993) 21218–21224. [PMID: 8407958] |
| 3. |
Waters, T.R. and Swann, P.F. Kinetics of the action of thymine DNA glycosylase. J. Biol. Chem. 273 (1998) 20007–20014. [DOI] [PMID: 9685338] |
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| [EC 3.2.2.29 created 2009] |
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