The Enzyme Database

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EC 3.2.2.25     
Accepted name: N-methyl nucleosidase
Reaction: 7-methylxanthosine + H2O = 7-methylxanthine + D-ribose
For diagram of caffeine biosynthesis, click here
Other name(s): 7-methylxanthosine nucleosidase; N-MeNase; N-methyl nucleoside hydrolase; methylpurine nucleosidase
Systematic name: 7-methylxanthosine ribohydrolase
Comments: The enzyme preferentially hydrolyses 3- and 7-methylpurine nucleosides, such as 3-methylxanthosine, 3-methyladenosine and 7-methylguanosine. Hydrolysis of 7-methylxanthosine to form 7-methylxanthine is the second step in the caffeine-biosynthesis pathway.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Negishi, O., Ozawa, T. and Imagawa, H. N-Methyl nucleosidase from tea leaves. Agric. Biol. Chem. 52 (1988) 169–175.
[EC 3.2.2.25 created 2007]
 
 


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