EC |
3.2.2.20 |
Accepted name: |
DNA-3-methyladenine glycosylase I |
Reaction: |
Hydrolysis of alkylated DNA, releasing 3-methyladenine |
Other name(s): |
deoxyribonucleate 3-methyladenine glycosidase I; 3-methyladenine DNA glycosylase I; DNA-3-methyladenine glycosidase I |
Systematic name: |
alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine) |
Comments: |
Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 2.1.1.63 methylated-DNA—[protein]-cysteine S-methyltransferase). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 89287-37-6 |
References: |
1. |
Evensen, G. and Seeberg, E. Adaptation to alkylation resistance involves the induction of a DNA glycosylase. Nature 296 (1982) 773–775. [PMID: 7040984] |
2. |
Karran, P., Hjelmgren, T. and Lindahl, T. Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents. Nature 296 (1982) 770–773. [PMID: 7040983] |
3. |
Thomas, L., Yang, C.-H. and Goldthwait, D.A. Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine. Biochemistry 21 (1982) 1162–1169. [PMID: 7041972] |
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[EC 3.2.2.20 created 1990, modified 2000] |
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