| EC |
3.2.2.14 |
| Accepted name: |
NMN nucleosidase |
| Reaction: |
β-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + nicotinamide |
| Other name(s): |
NMNase; nicotinamide mononucleotide nucleosidase; nicotinamide mononucleotidase; NMN glycohydrolase; NMNGhase |
| Systematic name: |
nicotinamide-nucleotide phosphoribohydrolase |
| Comments: |
The enzyme is thought to participate in an NAD+-salvage pathway. In eukaryotic organisms this activity has been attributed to EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37237-49-3 |
| References: |
| 1. |
Andreoli, A.J., Okita, T.W., Bloom, R. and Grover, T.A. The pyridine nucleotide cycle: presence of a nicotinamide mononucleotide-specific glycohydrolase in Escherichia coli. Biochem. Biophys. Res. Commun. 49 (1972) 264–269. [DOI] [PMID: 4342726] |
| 2. |
Imai, T. Isolation and properties of a glycohydrolase specific for nicotinamide mononucleotide from Azotobacter vinelandii. J. Biochem. 85 (1979) 887–899. [PMID: 457634] |
| 3. |
Imai, T. Properties of allosteric nicotinamide mononucleotide glycohydrolase from Azotobacter vinelandii: activation and inhibition. J. Biochem. 101 (1987) 163–173. [PMID: 3571198] |
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| [EC 3.2.2.14 created 1976, modified 2018] |
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