The Enzyme Database

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EC 3.2.1.18     
Accepted name: exo-α-sialidase
Reaction: Hydrolysis of α-(2→3)-, α-(2→6)-, α-(2→8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates
Other name(s): neuraminidase; sialidase; α-neuraminidase; acetylneuraminidase
Systematic name: acetylneuraminyl hydrolase
Comments: The enzyme does not act on 4-O-acetylated sialic acids. endo-α-Sialidase activity is listed as EC 3.2.1.129, endo-α-sialidase. See also EC 4.2.2.15 anhydrosialidase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9001-67-6
References:
1.  Schauer, R. Sialic acids. Adv. Carbohydr. Chem. Biochem. 40 (1982) 131–234. [PMID: 6762816]
2.  Cabezas, J.A. Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase. Biochem. J. 278 (1991) 311–312. [PMID: 1883340]
[EC 3.2.1.18 created 1961, modified 1999]
 
 


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