The Enzyme Database

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EC 3.2.1.143     
Accepted name: poly(ADP-ribose) glycohydrolase
Reaction: hydrolyses poly(ADP-D-ribose) at glycosidic (1′′-2′) linkage of ribose-ribose bond to produce free ADP-D-ribose
For diagram of reaction, click here
Glossary: ADP-D-ribose = adenosine 5′-(5-deoxy-D-ribofuranos-5-yl diphosphate)
Comments: Specific to (1′′-2′) linkage of ribose-ribose bond of poly(ADP-D-ribose).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9068-16-0
References:
1.  Miwa, M. and Sugimura, T. Splitting of the ribose-ribose linkage of poly(adenosine diphosphate-ribose) by a calf thymus extract. J. Biol. Chem. 246 (1971) 6362–6364. [PMID: 4331388]
2.  Lin, W., Ame, J.C., Aboul-Ela, N., Jacobson, E.L. and Jacobson, M.K. Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase. J. Biol. Chem. 272 (1997) 11895–11901. [PMID: 9115250]
[EC 3.2.1.143 created 2000]
 
 


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