| EC |
3.1.6.15 |
| Accepted name: |
N-sulfoglucosamine-3-sulfatase |
| Reaction: |
Hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin |
| Other name(s): |
chondroitinsulfatase |
| Systematic name: |
N-sulfo-3-sulfoglucosamine 3-sulfohydrolase |
| Comments: |
The enzyme from Flavobacterium heparinum also hydrolyses N-acetyl-D-glucosamine 3-O-sulfate; the mammalian enzyme acts only on the disulfated residue. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Bruce, J.S., McLean, M.W., Long, W.F. and Williamson, F.B. Flavobacterium heparinum 3-O-sulphatase for N-substituted glucosamine 3-O-sulphate. Eur. J. Biochem. 148 (1985) 359–365. [DOI] [PMID: 3987694] |
| 2. |
Leder, I.G. A novel 3-O sulfatase from human urine acting on methyl-2-deoxy-2-sulfamino-α-D-glucopyranoside 3-sulfate. Biochem. Biophys. Res. Commun. 94 (1980) 1183–1189. [DOI] [PMID: 7396957] |
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| [EC 3.1.6.15 created 1984, modified 1989] |
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