The Enzyme Database

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EC 3.1.6.12     
Accepted name: N-acetylgalactosamine-4-sulfatase
Reaction: Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate
For diagram of the later stages of chondroitin biosynthesis, click here
Other name(s): chondroitinsulfatase; chondroitinase; arylsulfatase B; acetylgalactosamine 4-sulfatase; N-acetylgalactosamine 4-sulfate sulfohydrolase
Systematic name: N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase
Comments: Acts also on N-acetylglucosamine 4-sulfate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 55354-43-3
References:
1.  Farooqui, A.A. The desulphation of hexosamine sulphates by arylsulphatase B. Experientia 32 (1976) 1242–1244. [PMID: 976430]
2.  Gorham, S.D. and Cantz, M. Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide. Hoppe-Seyler's Z. Physiol. Chem. 359 (1978) 1811–1814. [PMID: 738706]
3.  Tsuji, M., Nakanishi, Y., Habuchi, H., Ishihara, K. and Suzuki, S. The common identity of UDP-N-acetylgalactosamine 4-sulfatase, nitrocatechol sulfatase (arylsulfatase), and chondroitin 4-sulfatase. Biochim. Biophys. Acta 612 (1980) 373–383. [PMID: 7370276]
[EC 3.1.6.12 created 1984]
 
 


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