| EC |
3.1.6.12 |
| Accepted name: |
N-acetylgalactosamine-4-sulfatase |
| Reaction: |
Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate |
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For diagram of the later stages of chondroitin biosynthesis, click here |
| Other name(s): |
chondroitinsulfatase; chondroitinase; arylsulfatase B; acetylgalactosamine 4-sulfatase; N-acetylgalactosamine 4-sulfate sulfohydrolase |
| Systematic name: |
N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase |
| Comments: |
Acts also on N-acetylglucosamine 4-sulfate. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 55354-43-3 |
| References: |
| 1. |
Farooqui, A.A. The desulphation of hexosamine sulphates by arylsulphatase B. Experientia 32 (1976) 1242–1244. [PMID: 976430] |
| 2. |
Gorham, S.D. and Cantz, M. Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide. Hoppe-Seyler's Z. Physiol. Chem. 359 (1978) 1811–1814. [PMID: 738706] |
| 3. |
Tsuji, M., Nakanishi, Y., Habuchi, H., Ishihara, K. and Suzuki, S. The common identity of UDP-N-acetylgalactosamine 4-sulfatase, nitrocatechol sulfatase (arylsulfatase), and chondroitin 4-sulfatase. Biochim. Biophys. Acta 612 (1980) 373–383. [DOI] [PMID: 7370276] |
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| [EC 3.1.6.12 created 1984] |
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