| EC |
3.1.4.37 |
| Accepted name: |
2′,3′-cyclic-nucleotide 3′-phosphodiesterase |
| Reaction: |
nucleoside 2′,3′-cyclic phosphate + H2O = nucleoside 2′-phosphate |
| Other name(s): |
cyclic-CMP phosphodiesterase; 2′,3′-cyclic AMP phosphodiesterase; cyclic 2′,3′-nucleotide 3′-phosphodiesterase; cyclic 2′,3′-nucleotide phosphodiesterase; 2′,3′-cyclic nucleoside monophosphate phosphodiesterase; 2′,3′-cyclic nucleotide 3′-phosphohydrolase; CNPase; 2′,3′-cyclic nucleotide phosphohydrolase; 2′:3′-cyclic nucleotide 3′-phosphodiesterase; 2′:3′-CNMP-3′-ase |
| Systematic name: |
nucleoside-2′,3′-cyclic-phosphate 2′-nucleotidohydrolase |
| Comments: |
The brain enzyme acts on 2′,3′-cyclic AMP more rapidly than on the UMP or CMP derivatives. An enzyme from liver acts on 2′,3′-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyses the corresponding 3′,5′-cyclic phosphates, but more slowly. This latter enzyme has been called cyclic-CMP phosphodiesterase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 60098-35-3 |
| References: |
| 1. |
Drummond, G.I., Iyer, N.T. and Keith, J. Hydrolysis of ribonucleoside 2′,3′-cyclic phosphates by a diesterase from brain. J. Biol. Chem. 237 (1962) 3535–3539. |
| 2. |
Helfman, D.M. and Kuo, J.F. A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2′:3′- and 3′:5′-nucleotides. J. Biol. Chem. 257 (1982) 1044–1047. [PMID: 6274851] |
| 3. |
Helfman, D.M., Shoji, M. and Kuo, J.F. Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP. J. Biol. Chem. 256 (1981) 6327–6334. [PMID: 6263914] |
| 4. |
Kurihara, T., Nishizawa, Y., Takahashi, Y. and Odani, S. Chemical, immunological and catalytic properties of 2′:3′-cyclic nucleotide 3′-phosphodiesterase purified from brain white matter. Biochem. J. 195 (1981) 153–157. [PMID: 6272743] |
| 5. |
Nishizawa, Y., Kurihara, T. and Takahashi, Y. Spectrophotometric assay, solubilization and purification of brain 2′:3′-cyclic nucleotide 3′-phosphodiesterase. Biochem. J. 191 (1980) 71–82. [PMID: 6258586] |
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| [EC 3.1.4.37 created 1976] |
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