| EC |
3.1.3.99 |
| Accepted name: |
IMP-specific 5′-nucleotidase |
| Reaction: |
IMP + H2O = inosine + phosphate |
| Other name(s): |
ISN1 (gene name) |
| Systematic name: |
inosine 5′-phosphate phosphohydrolase |
| Comments: |
The enzyme, isolated from the yeast Saccharomyces cerevisiae, is highly specific for inosine 5′-phosphate, and has no detectable activity with other purine and pyrimidine nucleotides. Requires divalent metals, such as Mg2+, Co2+ or Mn2+. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9027-73-0 |
| References: |
| 1. |
Itoh, R. Purification and some properties of an IMP-specific 5′-nucleotidase from yeast. Biochem. J. 298 (1994) 593–598. [PMID: 8141771] |
| 2. |
Itoh, R., Saint-Marc, C., Chaignepain, S., Katahira, R., Schmitter, J.M. and Daignan-Fornier, B. The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5′-nucleotidase. BMC Biochem. 4:4 (2003). [DOI] [PMID: 12735798] |
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| [EC 3.1.3.99 created 2016] |
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