The Enzyme Database

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EC 3.1.3.88     
Accepted name: 5′′-phosphoribostamycin phosphatase
Reaction: 5′′-phosphoribostamycin + H2O = ribostamycin + phosphate
For diagram of neamine and ribostamycin biosynthesis, click here
Other name(s): btrP (gene name); neoI (gene name)
Systematic name: 5′′-phosphoribostamycin phosphohydrolase
Comments: Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. No metal is required for activity.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Kudo, F., Fujii, T., Kinoshita, S. and Eguchi, T. Unique O-ribosylation in the biosynthesis of butirosin. Bioorg. Med. Chem. 15 (2007) 4360–4368. [PMID: 17482823]
[EC 3.1.3.88 created 2012]
 
 


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