This reaction is a shortcut in the Rapoport-Luebering shunt. It bypasses the reactions of EC 22.214.171.124/EC 126.96.36.199 [phosphoglycerate mutases (2,3-diphosphoglycerate-dependent and independent)] and directly forms 2-phospho-D-glycerate by removing the 3-phospho-group of 2,3-diphospho-D-glycerate . The MIPP1 protein also catalyses the reaction of EC 188.8.131.52 (multiple inositol-polyphosphate phosphatase).
Cho, J., King, J.S., Qian, X., Harwood, A.J. and Shears, S.B. Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. Proc. Natl. Acad. Sci. USA105 (2008) 5998–6003. [DOI] [PMID: 18413611]