The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 3.1.3.74     
Accepted name: pyridoxal phosphatase
Reaction: pyridoxal 5′-phosphate + H2O = pyridoxal + phosphate
Other name(s): vitamine B6 (pyridoxine) phosphatase; PLP phosphatase; vitamin B6-phosphate phosphatase; PNP phosphatase
Systematic name: pyridoxal-5′-phosphate phosphohydrolase
Comments: Requires Mg2+. This enzyme is specific for phosphorylated vitamin B6 compounds: it acts not only on pyridoxal phosphate (PLP), but also on pyridoxine phosphate (PNP), pyridoxamine phosphate (PMP), 4-pyridoxic acid phosphate and 4-deoxypyridoxine phosphate. This reaction can also be carried out by EC 3.1.3.1 (alkaline phosphatase) and EC 3.1.3.2 (acid phosphatase), but these enzymes have very broad substrate specificities.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9076-92-0
References:
1.  Fonda, M.L. Purification and characterization of vitamin B6-phosphate phosphatase from human erythrocytes. J. Biol. Chem. 267 (1992) 15978–15983. [PMID: 1322411]
2.  Fonda, M.L. and Zhang, Y.N. Kinetic mechanism and divalent metal activation of human erythrocyte pyridoxal phosphatase. Arch. Biochem. Biophys. 320 (1995) 345–352. [PMID: 7625842]
3.  Jang, Y.M., Kim, D.W., Kang, T.C., Won, M.H., Baek, N.I., Moon, B.J., Choi, S.Y. and Kwon, O.S. Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution. J. Biol. Chem. 278 (2003) 50040–50046. [PMID: 14522954]
[EC 3.1.3.74 created 2004]
 
 


Data © 2001–2017 IUBMB
Web site © 2005–2017 Andrew McDonald