ExplorEnz: EC 3.1.3.67

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3.1.3.67

Accepted name:

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

Reaction:

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H₂O = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate

For diagram of 1-phosphatidyl-myo-inositol metabolism, click here

Glossary:

inositol 1,4,5-trisphosphate = Ins(1,4,5)P₃
inositol 1,3,4,5-tetrakisphosphate = Ins(1,3,4,5)P₄
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P₂
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P₃

Other name(s):

PTEN (gene name); MMAC1 (gene name); phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase

Systematic name:

1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase

Comments:

Requires Mg²⁺. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P₄ to Ins(1,4,5)P₃

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 210488-47-4

References:

1.	Kabuyama, Y., Nakatsu, N., Homma, Y., Fukui, Y. Purification and characterization of phosphatidyl inositol-3,4,5-trisphosphate phosphatase in bovine thymus. Eur. J. Biochem. 238 (1996) 350–356. [DOI] [PMID: 8681945]
2.	Maehama, T. and Dixon, J.E. The tumor suppressor, PTEN /MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273 (1998) 13375–13378. [DOI] [PMID: 9593664]

[EC 3.1.3.67 created 1999, modified 2002]