EC |
3.1.3.47 |
Accepted name: |
[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase |
Reaction: |
[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O = [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate |
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For diagram of mevalonate biosynthesis, click here |
Other name(s): |
reductase phosphatase |
Systematic name: |
[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphate phosphohydrolase |
Comments: |
Acts on the product of the reaction catalysed by EC 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, simultaneously dephosphorylating and activating EC 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 73507-97-8 |
References: |
1. |
Gil, G. and Hegardt, F.G. Some properties of purified 3-hydroxy-3-methylglutaryl coenzyme A reductase phosphatases from rat liver. Arch. Biochem. Biophys. 214 (1982) 192–198. [DOI] [PMID: 6282220] |
2. |
Gil, G., Sitges, M. and Hegardt, F.G. Purification and properties of rat liver hydroxymethylglutaryl coenzyme A reductase phosphatases. Biochim. Biophys. Acta 663 (1981) 211–221. [DOI] [PMID: 6260210] |
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[EC 3.1.3.47 created 1984] |
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